Ocrelizumab for Psychoses Possibly Caused by Synaptic Autoimmunity

Summary

Some people who have what doctors currently call schizophrenia or bipolar disease may actually have a brain disease caused by auto-antibodies. Auto-antibodies are produced when the normal defense mechanism of the body goes wrong and begins to attack the body, similar to "friendly fire." Auto-antibodies attack brain receptors and then the person who has this problem begins to have hallucinations and other manifestations of schizophrenia, like feeling that people can see what they are thinking and also feeling that other people do not like them. If this disease is caused by auto-antibodies, typically the person is well until they are 15 years of age or older, but seldom older than 35 years. Then, in a matter of a few months they begin to have hallucinations and the other symptoms. Doctors still do not know whether some people with schizophrenia or bipolar disease have auto-antibodies attacking their brain. For this reason, in this study some of these patients will receive a treatment that suppresses the auto-antibodies and their symptoms after treatment will be compared with the symptoms of a group of similar patients who are given a preparation that looks like the real treatment, but it is not.

Eligibility

Age range

18–35 years

Sex

All

Healthy volunteers

No

Interventions

• Behavioral
  Psychosis and cognitive assessments

  Administration of MINI, PANSS and Quality of Living scales

• Behavioral
  Physical and neuro-cognitive evaluations

  Physical, neurological and cognitive evaluations.

• Diagnostic Test
  Safety labs and electrocardiogram

  Metabolic panel, CBC and differential, urinalysis, ECG, recreational drugs. CD19+ B-cell count.

• Biological
  Ocrelizumab infusion

  Two IV infusions of 300 mg of ocrelizumab 2 weeks apart

Location