Outcomes Related to Body Composition in Teens and Adults With Cystic Fibrosis (ORBIT-CF)
Emory University
Summary
Nutrition and body composition, the amount of muscle and fat in the body, has a role in overall health. This study wants to learn more about how nutrition and body composition affects health outcomes like glucose tolerance and lung function in patients with cystic fibrosis (CF) who are ages 16-30 years old. 60 adolescents and young adults with CF will be recruited, and 30 volunteers without cystic fibrosis. A total of 40 of these study participants with CF will be asked to return for annual study visits for 2 years after the first visit. The long-term goal of this study is to use the information collected to make decisions about future nutrition monitoring and interventions which help maintain optimal health for individuals with CF.
Description
This is a prospective, observation study to test the central hypothesis that individuals with cystic fibrosis (CF) have a higher propensity to increased visceral adipose tissue (VAT) accumulation and decreased lean body mass (LBM) compared to healthy controls, and this dysregulation in adipose and protein deposition exacerbates glucose intolerance and lung function decline. A sub-set of participants with CF will be followed longitudinally for two years (n=40). The investigators will conduct detailed body composition, fat distribution, metabolic, and nutritional phenotyping in this cohort. Body…
Eligibility
- Age range
- 16+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: CF inclusion criteria 1. confirmed CF diagnosis based on sweat testing by pilocarpine iontophoresis and/or CFTR genotyping with two disease causing mutations 2. be aged ≥ 16 yrs 3. clinically stable, defined as no changes in medical regimen (including medications) for at least 21 days prior to study visit 4. participation in the CFF Patient Registry Longitudinal study inclusion: CF participants who have normal glucose tolerance results after their initial study oral glucose tolerance test (OGTT). Healthy controls inclusion criteria: 1. male or female ages 16 years and…
Locations (2)
- University of Alabama at Birmingham (UAB)/Children's of AlabamaBirmingham, Alabama
- Emory University/Children's Hospital of Atlanta (CHOA)Atlanta, Georgia