University of California, Los Angeles
This study will analyze the feasibility, safety, and tolerability of administering repetitive Transcranial magnetic stimulation(TMS) at frequencies other than standard 10 Hz. This study will enroll 50 subjects who will undergo one quantitative electroencephalograph, one TMS procedure to determine the appropriate frequency and intensity for treatment, weekly mood/symptom assessments, and up to 30 TMS treatments. Subjects will be asked to participate for up to 6 weeks.
The therapeutic benefit of repetitive Transcranial Magnetic Stimulation (rTMS) for the treatment of Major Depressive Disorder (MDD) is thought to depend upon engagement of brain functional networks (FNs). Engagement is dependent upon an interaction between the rTMS stimulation frequency and the preferred oscillatory frequency of the target network for that individual. We report here on a novel method to interrogate the left dorsolateral prefrontal cortex (DLPFC) treatment target to identify the optimal frequency for engagement of the frontoparietal control network (FCN) for each individual. 23…
Inclusion Criteria: * All subjects must be over between 18-65 years of age. * Must have confirmed diagnosis of severe Major Depressive Disorder (single or recurrent episode). * Failure to respond to a minimum of 4 trials of antidepressant medication * Failure to respond from at least two different agent classes * Accompanied by at least two evidence-based augmentation therapies (Benzodiazepines do not count). * Must have a trial of psychotherapy known to be effective in the treatment of MDD of an adequate frequency and duration. * Subjects are willing and able to adhere to the treatment sched…
Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression. Using pulsed magnetic fields, transcranial magnetic stimulation therapy stimulates the part of the brain thought to be involved with mood regulation. These magnetic fields do not directly affect the whole brain; they only reach about 2-3 centimeters into the brain directly beneath the treatment coil.As these magnetic fields move into the brain, they produce very small electrical currents. These electrical currents activate cells within the brain, causing them to rewire, a process called neuroplasticity.
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