Mayo Clinic
This clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intra- and post-operative microdialysis during neurosurgery for central nervous system malignancies. A biomarker is a measurable indicator of the severity or presence of disease state. Information collected in this study may help doctors develop new strategies to better diagnose, monitor, and treat brain tumors.
PRIMARY OBJECTIVE: I. Determine biomarkers of in situ gliomas across a diverse patient cohort using intra- or post-operative microdialysis to sample extracellular metabolites and other analytes. SECONDARY OBJECTIVE: I. Evaluate the yield and specificity of microdialysate D-2HG as a candidate tumor biomarker to differentiate between IDH-mutated and IDH-wildtype gliomas. II. Identify biomarkers of tumor-associated processes including brain edema, brain infiltration with non-enhancing tumor, and tumor-associated hypoxia or necrosis. III. Determine the contribution of blood-brain barrier disr…
Inclusion Criteria: * Age \>= 18 years * Diagnosis of the following, based on clinical and radiographic evidence: * Any glioma * Metastatic brain tumor of any primary origin * Epileptic focus requiring surgical resection * Planned neurosurgical procedure for purposes of biopsy or resection of suspected or previously diagnosed brain tumor (primary or metastatic) or epileptic focus as part of routine clinical care * Willing to undergo neurosurgical resection or biopsy at Mayo Clinic \[Rochester, Minnesota (MN)\] * For patients with gliomas recruited for post-operative microdialysis, will…
Undergo microdialysis
Undergo MRI
Undergo CT
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