Roswell Park Cancer Institute
This phase II trial studies how well respiratory muscle training before surgery works in preventing lung complications after surgery in patients with stage I-IIIB lung cancer. Patients with lung cancer who choose to undergo surgical resection often have complications after surgery such as pneumonia, unplanned intubations, difficulty breathing and reduced physical functioning, and increased medical costs and a reduced quality of life. Improving pre-surgical pulmonary health through respiratory muscle training may improve respiratory muscle strength, response to surgery, and quality of life after surgery in patients with lung cancer.
PRIMARY OBJECTIVES: I. Assess the impact of a short-duration respiratory muscle training (RMT) program on respiratory muscle strength in patients undergoing resection for lung cancer. SECONDARY OBJECTIVES: I. Compare the extent of diaphragm atrophy and catabolic/anabolic pathway activation between RMT responders and non-responders evaluated for gene expression and candidate and candidate causative protein levels. II. Determine the effect of the short-duration RMT program on health related quality-of-life measures. III. Assess the impact of the short-duration RMT program on postoperative o…
Inclusion Criteria: * Documented stage I-IIIb lung cancer or is undergoing surgery for diagnosis * Participant is able to speak, read, and comprehend English * Participant must be undergoing or is anticipated to either video-assisted thoracic surgery (VATS or robotic surgery) or laparoscopic surgery for curative intent lung resection * Patients with or without neoadjuvant chemoradiotherapy (CRT) prior to surgery will be included * Ability to follow written and verbal instructions * Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/In…
Receive usual care
Undergo laparoscopic surgery
Ancillary studies
Ancillary studies
Use power lung device to complete RMT
Undergo video-assisted thoracic surgery