Vanderbilt University Medical Center
The investigator proposes to study electrical activity reflective of esophageal motility in adults noninvasively by the use of multichannel electroesophagogram (EESG) and magnetoesophagogram (MESG) recordings.
Dysphagia, or difficulty with swallowing, is a common symptom affecting nearly 9.4 million individuals or 4% of the US population. High resolution esophageal manometry is currently considered the gold standard test for evaluation and diagnosis of esophageal motility disorders, but given that it requires trans-nasal placement in a conscious patient, this test is highly uncomfortable and associated with significant patient dissatisfaction. There are currently no noninvasive tests or markers available to test esophageal function and motility. In the upper gastrointestinal system, as in the heart…
Inclusion Criteria: * Adults ≥ 18 years of age who are undergoing HRM for routine standard of care evaluation for esophageal motility. * Normal control participants (ages ≥ 18 years) who have no known gastrointestinal complications. Exclusion Criteria: * Those with claustrophobia who cannot lie still under the SQUID for the length of time required * Due to interference with signal acquisition, subjects with contraindication to undergoing an MRI scan as noted in the MRI Safety checklist by Vanderbilt University Medical Center (such as with heart pacemakers, metal implants, or metal chips or…
Collection of patient reported symptoms and perception of health
Use of silver-silver chloride cutaneous electrogastrogram (EGG) electrodes to get myoelectrical readings
MESG measures spatiotemporal properties of magnetic fields from the esophageal slow wave and allows characterization of the propagation of the slow wave in addition to evaluation of its frequency and power distribution
Dysphagia subjects will have undergone standard of care HRM to determine placement in the achalasia or hypercontractile/spastic disorder arms
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