VA Office of Research and Development
This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.
The specific aim of this project is to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia. This study will recruit patients with a history of mild-moderate traumatic brain injury, mild cognitive impairment, as well as healthy controls in order to better understand how single or repetitive mild Traumatic brain injuries may contribute to the development of dementia. It will be prospective in nature. Participants will be asked to co…
Inclusion Criteria: All Subjects: * Intact color vision * Visual acuity of 20/30 (or better) * Patients must pass effort measures on the TOMM * Patients must have intact decision-making capacity * Patients must have no contraindications to lumbar puncture including: * Being on a blood thinner * Aspirin or Plavix * Have no space occupying lesion on magnetic resonance imaging (MRI) * An International Normalized Ratio (INR) value \< 1.4 and platelet count \>50,000 * No epidural infection or overlying cellulitis over the lumbar spine * PTSD will be accounted for as a potential confounder and its…
No intervention will be used.
No intervention will be used.
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