Assessment of Left Ventricular Volumes and Strain and Assessment of Valvular Lesions Using Two- and Three-dimensional Echocardiography and Cardiac MRI, a Correlation Study
The Cleveland Clinic
Summary
The purpose of the study is to compare the various 2D and 3D methods of valvular heart disease quantification (Doppler, PISA, VCA, volumetric method) and strain with cardiac magnetic resonance (CMR) measurements of left and right ventricular systolic function strain and myocardial fibrosis assessment.
Description
The objective of this study is to compare the accuracy of 3D TTE to 2D TTE in assessing the severity of valvular heart disease in patients with aortic stenosis, aortic regurgitation, and mitral valve regurgitation by comparing this to the reference standard of cardiac magnetic resonance (CMR) in subjects with different etiologies and mechanisms of valvular lesions and to the integrative method of valvular lesion grading as recommended by inter-societal guidelines. Another objective is to assess prevalence of focal and diffuse myocardial fibrosis as assessed by CMR in patients with aortic steno…
Eligibility
- Age range
- 18–90 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age 18-90 years of age * Suspected moderate or severe MR,AR or AS on the basis of prior known clinical history or clinical exam. * Suspected CRT "non-responder" with an implanted MRI compatible CRT device and reduced ejection fraction Exclusion Criteria: * Acute traumatic cardiac injury * Aortic dissection or aortic root rupture * Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD * Presence of A-V fistula or intracardiac shunts * Any contraindications to CMR * Moderate or severe dysfunction in multiple valves * Patients with…
Interventions
- Diagnostic TestMRI with strain measurement
CMR measurements of left and right ventricular systolic function strain and myocardial fibrosis
- Diagnostic TestEchocardiography
Doppler, PISA, VCA, volumetric method as performed during echocardiography
Location
- Cleveland ClinicCleveland, Ohio