University of Texas at Austin
Early life influences (including the intrauterine environment, birth weight, and early postnatal growth) shape subsequent weight trajectories and future chronic disease risk. The MINT study will evaluate whether maternal fat mass changes are associated with specific maternal weight trajectories during pregnancy, and with neonatal adiposity at birth. The study is a prospective observational cohort currently enrolling women in early pregnancy,and following mothers and infants after birth.
The Institute of Medicine (IOM) recommendations were established with limited evidence showing how the pattern of weight gain is associated with short-and long-term health of mothers and their children. Previous studies evaluated the impact of overall gestational weight gain pattern across gestation using latent class analysis and others have evaluated maternal weight change pattern-by trimester or early/late pregnancy-on offspring size and adiposity. However, it remains unclear if there are weight gain trajectories or specific periods of weight gain that are associated with greater adiposity…
Inclusion Criteria: 1. \<16 weeks gestation 2. Age \>18 years old 3. BMI \<35 kg/m2 4. Width \<48 cm Exclusion Criteria: 1. Diabetes 2. Claustrophobia 3. Recent weight loss of \>5% of body weight before pregnancy 4. Weight-loss related surgery 5. Currently breastfeeding 6. Smoking 7. Presence of any mechanically or magnetically activated implants, or any other contraindication for MRI
This is an observational study.
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