Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms
University of Miami
Summary
The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Undergoing one of the following procedures at Jackson Memorial Hospital: * Clipping of an unruptured cerebral artery aneurysm * Endovascular treatment of unruptured cerebral aneurysms (including those receiving coiling) 2. ≥ 18 years of age 3. Willing and able to give informed consent Exclusion Criteria: 1\) Subjects meeting any of the following criteria will be excluded: * Dissecting, traumatic, or mycotic brain aneurysm. * Women who are pregnant, or have a positive urine or blood (β-hCG) pregnancy test. * Women who are breastfeeding. * Any clinically signifi…
Interventions
- ProcedureMicrosurgical clipping
Standard of care microsurgical clipping of an unruptured cerebral artery aneurysm.
- ProcedureEndovascular treatment
Standard of care endovascular treatment of an unruptured cerebral artery aneurysm.
- DrugSirolimus
Daily oral Sirolimus 2 mg tablets, adjusted as necessary per treating physician.
Location
- University of MiamiMiami, Florida