University of Miami
The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.
Inclusion Criteria: 1. Undergoing one of the following procedures at Jackson Memorial Hospital: * Clipping of an unruptured cerebral artery aneurysm * Endovascular treatment of unruptured cerebral aneurysms (including those receiving coiling) 2. ≥ 18 years of age 3. Willing and able to give informed consent Exclusion Criteria: 1\) Subjects meeting any of the following criteria will be excluded: * Dissecting, traumatic, or mycotic brain aneurysm. * Women who are pregnant, or have a positive urine or blood (β-hCG) pregnancy test. * Women who are breastfeeding. * Any clinically signifi…
Standard of care microsurgical clipping of an unruptured cerebral artery aneurysm.
Standard of care endovascular treatment of an unruptured cerebral artery aneurysm.
Daily oral Sirolimus 2 mg tablets, adjusted as necessary per treating physician.
Arctuva estimate
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