Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
University of California, Davis
Summary
Magnesium is a naturally occurring mineral that is important for your body and brain. Magnesium sulfate (study drug) is a medication containing magnesium that is commonly used to improve low blood levels of magnesium. Magnesium sulfate has also proven to be successful in managing pain before and after surgery. However, this drug has primarily been used for pain control in patients undergoing surgery. Patients in the ICU with injuries also need good pain control. Using magnesium may assist in decreasing narcotic (pain reliever) requirements and provide another non-narcotic drug for pain control. The purpose of this study is to test the effectiveness of continuous, intravenous (into or within a vein using a needle) administration of magnesium sulfate for pain control in trauma patients admitted to the adult Intensive Care Unit. This will be compared to intravenous normal saline (salt solution).
Description
This is a single center, double blind, randomized controlled study to demonstrate the effectiveness of continuous, intravenous administration of magnesium sulfate as compared to placebo in decreasing pain in critically injured patients. Study Hypothesis The primary hypothesis is that continuous infusion magnesium sulfate will significantly decrease opioid requirements and pain scores in critically ill patients. Background Magnesium is one of the most abundant cations in the human body. The physiologically active form of magnesium, ionized magnesium, is involved in hundreds of enzyme reaction…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * All trauma patients admitted to an adult intensive care unit * Signed informed consent * Hospital or trauma multimodal pain management order set used for pain management * Ages 18-99 Exclusion Criteria: * Admission to the Pediatric Intensive Care Unit. * Head Abbreviated Injury Score (AIS) of greater than 1 * Known heart failure with reduced ejection fraction (EF \< 40%) * Renal failure (GFR \< 60) * Cardiac arrhythmia (except for sinus tachycardia) * Greater than 5% TBSA burn injuries * Moderate to severe alcohol withdrawal protocol ordered for patient * Regular use o…
Interventions
- DrugMagnesium Sulfate in Parenteral Dosage Form
IV bolus followed by continuous infusion for 24 hours
- DrugNormal saline placebo
IV bolus followed by continuous infusion for 24 hours
Location
- UC Davis HealthSacramento, California