Molecular Genetics Studies of Cancer Patients and Their Relatives
City of Hope Medical Center
Summary
This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.
Description
PRIMARY OBJECTIVES: I. To identify rare cancer patients and families in whom the pattern of disease suggests a genetic susceptibility to cancer or other etiology suggestive of a carcinogenic exposure and to characterize the underlying predisposition. II. To determine the contribution of heredity (genotype) and biomarkers to clinical outcome (phenotype, occurrence of new cancers, prognosis and quality of life) in subgroups of cancer patients with and without clinical high-risk features. OUTLINE: Patients may provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Individuals must have a personal history of cancer and/or a family history of cancer suggestive of the presence of an inherited predisposition. This inherited predisposition might manifest as: * Young age cancer diagnosis * Multiple primary neoplasms in affected member * The presence of rare tumor types in the family * Congenital malformations * Any other family clustering of cancer * Any other cancer-predisposing genetic diseases/conditions * Individuals may also be eligible by participation in the City of Hope Cancer Screening \& Prevention Program Network…
Interventions
- OtherBiospecimen Collection
Provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue
- OtherQuestionnaire Administration
Ancillary studies
Locations (42)
- Valleywise Comprehensive Health Center - PhoenixPhoenix, Arizona
- John Muir Medical Center-Concord CampusConcord, California
- City of Hope Medical CenterDuarte, California
- Saint Jude Medical CenterFullerton, California
- Saddleback Memorial Medical CenterLaguna Hills, California
- USC / Norris Comprehensive Cancer CenterLos Angeles, California