Heart Failure Precision Medicine Study
University of California, Davis
Summary
The study aims to test the hypothesis that multi-omics studies can identify Heart Failure profiles at risk of adverse outcomes and evaluate a telemonitoring intervention in the optimization of guideline-directed medical therapy.
Description
In the US, the estimated prevalence of Heart Failure (HF) is 6.2 million and increasing. The mortality approaches 50% within 5 years of diagnosis and HF is the main cause of hospitalization among patients over 65 years of age. Information on molecular states may enhance understanding of causes and pathophysiological processes, improve risk prediction, identify new therapeutic targets, and improve subclassification for targeted therapy. Time-dependent phenomapping has been used to identify clinical and genomic differences in a longitudinal fashion, which provides a mechanistic link underlying p…
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosis of Heart failure * Objective evidence of cardiac abnormality of structure or function (abnormal ECHO) or elevated levels of B-type natriuretic peptide (\>100 pg/ml) * HF stage B-D and class I-IV Exclusion Criteria: * Patients unable to consent * Inability to comply with the protocol and follow-up requirements * Patients unable to use a smartphone * Patients assessed irregularly (less than two visits in one year) * History of HTx * Use of Mechanical circulatory support device (MCSD) * Comorbidities that, according to the PI, have the potential to interfere wit…
Interventions
- DeviceTelemonitoring devices
Set of telemonitoring devices: heart rate and blood pressure monitor, scale and activity tracker.
Location
- UC Davis Medical CenterSacramento, California