Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
University of Florida
Summary
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.
Description
The overall project goals are to determine oxytocin effects on oxycodone's subject-rated abuse liability, experimental pain, and to describe the neurobehavioral mechanisms underlying interindividual differences in these effects. Generally healthy individuals (determined via medical history review and a screening session) will, after informed consent, self-administer intranasal oxytocin (or placebo, containing the same ingredients but no oxytocin) shortly after oral oxycodone or placebo in a non-residential, double-blind, randomized, placebo-controlled, within-subjects laboratory study. Prescre…
Eligibility
- Age range
- 21–45 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Individuals fluent in English will participate. * Must report recreational use of opioids. * Be within 20% of their ideal body weight. * Are not currently experiencing chronic pain (pain on most days during the past 3 months) * Have a systolic blood pressure of \<=140 and diastolic blood pressure of \<= 90, and a heart rate \<= 90 beats per minute. * Participants must also have a normal electrocardiogram (EKG) reading and bloodwork indicating no major health contraindications. Exclusion criteria: * Significant current physical disease or major psychiatric disorder. * N…
Interventions
- DrugOxyCODONE 5 mg Oral Tablet
Oral oxycodone 5 mg orally
- DrugOxytocin nasal spray
Intranasal oxytocin administration (48 IU)
- OtherPlacebo Oxycodone
Oxycodone 0 mg orally
- OtherPlacebo oxytocin
Intranasal placebo administration
- DrugOxyCODONE 2.5 mg Oral Tablet
Oral oxycodone 2.5 mg orally
Location
- University of FloridaGainesville, Florida