Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers
ECOG-ACRIN Cancer Research Group
Summary
The purpose of this study is to compare two approaches for monitoring pancreatic cysts as well as to identify associated biomarkers. The study doctors want to compare more frequent monitoring versus less frequent monitoring as well as identify biomarkers which may improve risk detection of transformation to pancreatic cancer. The study doctors want to learn which monitoring method and which biomarkers lead to better outcomes for patients.
Description
PRIMARY OBJECTIVE: I. Evaluate whether the protocol specified primary biomarkers (both blood and imaging-based) measured at baseline, are associated with the future development of worrisome features and/or high-risk stigmata. SECONDARY OBJECTIVES: I. Evaluate whether the imaging-based secondary biomarker implemented using baseline computed tomography (CT) scans and/or the blood-based secondary biomarker panel, is associated with the future development of worrisome features and/or high-risk stigmata. II. Estimate area under curve (AUC), sensitivity, specificity, negative, and positive predi…