ECOG-ACRIN Cancer Research Group
The purpose of this study is to compare two approaches for monitoring pancreatic cysts as well as to identify associated biomarkers. The study doctors want to compare more frequent monitoring versus less frequent monitoring as well as identify biomarkers which may improve risk detection of transformation to pancreatic cancer. The study doctors want to learn which monitoring method and which biomarkers lead to better outcomes for patients.
PRIMARY OBJECTIVE: I. Evaluate whether the protocol specified primary biomarkers (both blood and imaging-based) measured at baseline, are associated with the future development of worrisome features and/or high-risk stigmata. SECONDARY OBJECTIVES: I. Evaluate whether the imaging-based secondary biomarker implemented using baseline computed tomography (CT) scans and/or the blood-based secondary biomarker panel, is associated with the future development of worrisome features and/or high-risk stigmata. II. Estimate area under curve (AUC), sensitivity, specificity, negative, and positive predi…
Inclusion Criteria: * Patient must be ≥ 50 years and ≤ 75 years of age * Patient must not have acute pancreatitis or a history of chronic pancreatitis * Patient must have received a CT, MRI, or EUS within 6 months prior to enrollment that revealed one or more ≥ 1 cm pancreatic cyst(s). * Patients of childbearing potential must not be known to be pregnant * Patient must not have a prior diagnosis of pancreatic malignancy of any type * Patient must not have a history of pancreatic resection * Patients with only pancreatic lesions without malignant risk (pancreatic pseudocyst or classic serous c…
Undergo biopsy
Undergo blood sample collection
Undergo CT
Undergo EUS
Undergo EUS-FNA
Undergo MRI
Ancillary studies (PRIOR TO ADDENDUM #5 08/13/2024)
Ancillary studies (PRIOR TO ADDENDUM #5 08/13/2024)
Undergo surgery