A Pilot Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation
Case Comprehensive Cancer Center
Summary
The purpose of this study is to find a safe and tolerable way to improve engraftment after transplant. Research studies have shown that adding nicotinamide riboside to donor cells has the potential to increase blood stem cell numbers and potentially decrease the time to engraftment. Also, nicotinamide riboside, TRU NIAGEN (the study drug) is a type of vitamin B supplement that the general public can get without a prescription and is well tolerated.
Description
This is a single-center, pilot feasibility study of NR supplementation in allogeneic (donor) HCT in which the study team is seeking to obtain preliminary data on any beneficial effect of increasing NAD+ levels in-vivo to facilitate engraftment. Engraftment is defined as the process during which transplanted stem cells begin to grow in the bone marrow and produce new white blood cells, red blood cells, and platelets. It takes about 14 to 24 days for donor cells to engraft after infusion, and the time between which blood counts fall to the time when they recover is a very critical period. Transf…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * All disease indications for allogeneic hematopoietic cell transplantation except for myelofibrosis. * Subject must meet program eligibility criteria\* for myeloablative conditioning alloHCT and plan to undergo myeloablative conditioning. * HLA-identical related donor or unrelated human donor source with bone marrow graft. * Subjects must provide a written informed consent. Exclusion Criteria: * History of allergy or intolerance to NR precursor compounds, including niacin or nicotinamide * Pregnant or breastfeeding women are excluded from this study since allogeneic HCT…
Interventions
- DrugNicotinamide riboside (NR)
Nicotinamide riboside, PO, 500mgtwice daily for 21, 28, and 35 days
Location
- Cleveland Clinic, Case Comprehensive Cancer CenterCleveland, Ohio