Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer

Summary

This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy surgery is a procedure that removes a smaller number of lymph nodes from your neck because it uses an imaging agent to see which lymph nodes are most likely to have cancer. Standard neck dissection, such as elective neck dissection, removes many of the lymph nodes in your neck. Using sentinel lymph node biopsy surgery may work better in treating patients with early-stage oral cavity cancer compared to standard elective neck dissection.

Description

Eligibility

Age range

18+ years

Sex

All

Healthy volunteers

No

Interventions

• Procedure
  Chest Radiography

  Undergo chest x-ray

• Procedure
  Computed Tomography

  Undergo SPECT/CT scan and FDG PET/CT or CT

• Other
  Fludeoxyglucose F-18

  Undergo FDG PET/CT

• Drug
  Imaging Agent

  Receive imaging agent via injection

• Procedure
  Neck Dissection

  Undergo standard elective neck dissection

• Procedure
  Planar Imaging

  Undergo planar imaging

• Procedure
  Positron Emission Tomography

Locations (106)