The Olmsted NAFLD Epidemiology Study (TONES)
Mayo Clinic
Summary
Researchers are assessing the prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) in the population and assembling a well-characterized cohort of adults with NAFLD and NASH to validate models of NAFLD diagnosis and determine long-term outcomes.
Description
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease in the world and a major public health issue in the US. Recent information on the prevalence of NAFLD in general and Non-Alcoholic Steatohepatitis (NASH) with fibrosis in particular is very scarce. Such information is crucial for defining the epidemiology of NAFLD, identifying risk factors for advanced fibrosis and longitudinal outcomes. This study will enroll a random sample of adults from Olmsted County, Minnesota, to validate machine learning models for NAFLD diagnosis and disease severity. These dat…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Olmsted County residents at the time of search * Age 18 or older * No personal history of NAFLD diagnosis (administrative codes) Exclusion Criteria: * Alcohol in excess (more than 20 gm per week in women and 30 gm per week in men) * Currently pregnant * Have contraindications to MRI (MRI incompatible implanted devices, severe claustrophobia)
Interventions
- Diagnostic TestMagnetic Resonance Elastography
Combines MRI imaging with sound waves to create a visual map (elastogram) showing the stiffness of body tissues.
- OtherBlood draw
Clinical blood tests with a focus on liver function parameters and diabetes
- ProcedureLiver biopsy
If indicated per MRE results a biopsy will be taken of the liver.
- ProcedureFibro Scan
If indicated per MRE results a fibroscan will be performed of the liver.
Location
- Mayo Clinic in RochesterRochester, Minnesota