M.D. Anderson Cancer Center
This trial uses magnetic resonance elastography (MRE) to estimate tissue stiffness (hardness or softness of the tissue) in tissue that is affected by radiation treatment (radiation necrosis) and tumor tissue that has come back (recurrent) after treatment in patients with gliomas. Diagnostic procedures, such as MRE, may estimate the differences in tissue stiffness between radiation necrosis and recurrent glioma post treatment and ultimately lead to a more accurate diagnosis and/or surgery, and/or a better assessment of the disease's response to treatment.
PRIMARY OBJECTIVES: I. To estimate the mean lesion stiffness in patients with radiation necrosis using magnetic resonance elastography (MRE). II. To estimate the mean lesion stiffness in patients with glioma recurrence using magnetic resonance elastography (MRE). SECONDARY OBJECTIVE: I. To investigate the mean lesion stiffness between radiation necrosis and glioma recurrence. OUTLINE: Patients undergo MRE over 10 minutes and then undergo standard of care magnetic resonance imaging (MRI) of the brain with and without contrast at baseline. Within 4 weeks after the initial MRI and MRE scans…
Inclusion Criteria * \>/=18 years old. * History of a pathology proven intracranial glioma (including IDH mutant, IDH wildtype or 1p19q co-deleted tumors) treated with chemotherapy and radiation. * The lesion of concern (T2 Flair Hyperintense or contrast enhancing lesion) is \> 2 cm * Patient is able to understand and give consent to participation in the study. Exclusion Criteria * Patients less than 18 years of age. * Pregnant. * Known allergy to gadolinium-based contrast agents. * Renal failure as evidenced by a glomerular filtration rate (GFR) of less than 30 mL/min/1.73m2. * Pacemakers,…
Undergo MRE
Undergo standard of care MRI
Arctuva estimate
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