Sex-dependent Effects of Cannabis: Assessing Analgesic, Abuse-related and Pharmacokinetic Differences Between Men and Women
University of California, Los Angeles
Summary
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women
Description
The proposed study will compare smoked cannabis's dose-dependent, analgesic and abuse-related effects between men and women and variables that underlie these sex-dependent differences, including pharmacokinetics of THC.
Eligibility
- Age range
- 21–55 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Male or non-pregnant female aged 21-55 years * Report use of cannabis an average of 1-7 days per week * Not currently seeking treatment for their cannabis use * Urine test positive for recent cannabis use for heavy users * No reported adverse effects with cannabis smoking in light users * Have a Body Mass Index from 18.5 - 34kg/m2. * Able to perform all study procedures * FEMALES: Currently practicing a non-hormonal effective form of birth control * FEMALES: Must be regularly cycling Exclusion Criteria: * Meeting DSM-V criteria for any substance use disorder other than…
Interventions
- DrugActive Cannabis
Smoked cannabis with THC
- DrugPlacebo Cannabis
Placebo smoked cannabis (no THC)
Location
- University of California, Los AngelesLos Angeles, California