Objective and Subjective Measures of Fatigability in Veterans With Chronic Kidney Disease Before and After Flywheel Resistance Plus Aerobic Exercise
VA Office of Research and Development
Summary
The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease. Since the largest subpopulation of Veterans with chronic kidney disease is comprised of those not requiring dialysis, neuromuscular screening assessments may provide valuable information regarding an individual overall health status and potential for future complications. Furthermore, identifying at risk individuals early in the disease process will allow for the prescription of timely interventions. Exercise strategies such as combination exercise, which uses flywheel resistance plus aerobic exercise, may provide a valuable treatment option for combating neuromuscular dysfunction and functional decline in patients with chronic kidney disease.
Description
Chronic kidney disease (CKD) is a complex medical condition affecting as much as 36% of the Veteran population. Both empirical and anecdotal evidence identify elevations in fatigability as a major health concern in Veterans with CKD predialysis. Neuromuscular deteriorations resulting from CKD are likely to contribute to excessive fatigability, impacting an individual's functional status. Flywheel resistance exercise (FRE) uses inertial resistance to allow for optimal muscle loading through the entire concentric muscle action and promotes greater eccentric force generation compared to tradition…
Eligibility
- Age range
- 50–85 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Ambulatory (with or without a gait aid), 50 years of age or older diagnosed with chronic kidney disease (CKD) stages 3 \& 4 predialysis (as defined by eGFR 59-15 ml/min per 1.73m2) * Control group will include ambulatory individuals without clinical evidence of kidney disease (defined by eGRF \>60 ml/min per 1.73m2) within the last 12-months * All participants must be able to speak and read English, and demonstrate orientation to person, place, and time Exclusion Criteria: * adults diagnosed with acute renal failure/injury within the last 12-months * non-ambulatory ind…
Interventions
- BehavioralCombination Exercise
Flywheel Resistance Plus Aerobic Exercise
Location
- Washington DC VA Medical Center, Washington, DCWashington D.C., District of Columbia