Brigham and Women's Hospital
In this research study, is assessing the feasibility of using an MR-guided implantable microdevice to measure tumor response to chemotherapy and other clinically relevant drugs in participants that have prostate cancer and are scheduled for a radical prostatectomy. The name of the study intervention involved in this study is: \- Implantation of a MR-guided microdevice
This research study is assessing the feasibility and safety of implanting and retrieving a 'microdevice' that releases up to 20 drugs directly within the prostate cancer lesion as a possible tool to evaluate the effectiveness of several approved cancer drugs against prostate cancer. Participants will be identified with confirmed prostate cancer whose treatment plan includes surgery as a component of standard-of-care treatment. The name of the study intervention involved in this study is: * Implantation of a MR-guided microdevice . * It is expected that about 35 people will take part in this…
Eligibility Criteria: Ex Vivo Cohort * Inclusion Criteria * Participants must have the ability to understand and the willingness to sign a written informed consent document. * Planned radical prostatectomy for prostate cancer. * Participants must be 22 years of age or older. * Exclusion Criteria -- Unwillingness to sign informed consent. Eligibility Criteria: Surgical Cohort * Inclusion Criteria * Participants must have the ability to understand and the willingness to sign a written informed consent document. * Patients must have the ability to understand and the willingness to…
Surgery Cohort: Placement of 1-6 microdevices: Drugs chosen have all been FDA approved for the treatment of cancer (so therefore safe) and there are phase 2 or 3 data that the drug has efficacy in prostate cancer. Agents of interest included Abiraterone, Enzalutamide, Pembrolizumab, Ipilimumab, Carboplatin, Docetaxel, and Olaparib as well as combinations Ex vivo Cohort: Placement of multiple microdevices with miniature drug reservoirs but no drug is loaded into the removed prostate
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