Trajectory of Ovarian Morphology During the Adolescent Reproductive Transition
Cornell University
Summary
Establishment of regular menstrual cycles is a key component of reproductive maturation and a recognized vital sign for health and well-being. Irregular menstrual cycles are especially common for the first 2-3 years after an adolescent's first menstrual period (i.e., menarche), which delays the identification and diagnosis of early reproductive disturbances such as polycystic ovary syndrome (PCOS). The purpose of this research study is to determine whether the ovary can serve as a reliable predictor of normal or abnormal development by following the trajectory of ovarian morphology in conjunction with menstrual cyclicity using 3D transabdominal ultrasound imaging in a prospective cohort study of adolescents. A secondary objective is to identify potential environmental factors such as diet and the gut microbiome which influence the trajectory towards normal or abnormal reproductive development.
Description
Establishment of regular menstrual cycles is a key component of reproductive maturation and a recognized vital sign for health and well-being. Irregular menstrual cycles are especially common for the first 2-3 years after an adolescent's first menstrual period (i.e., menarche), which delays the identification and diagnosis of early reproductive perturbations and subsequent future disease risk. Therefore, the objectives of this study are to determine whether there are distinct aspects of ovarian morphology that predict the likelihood of regular menses or cycle irregularity at 2y post-menarche a…
Eligibility
- Age range
- 9–17 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Female adolescents aged 9 to 17 years * Menarche within 11 months of the enrollment visit * University of Rochester site only: Family history of PCOS (i.e., mother or aunt) Exclusion Criteria: * Current or recent use of medications or supplements known or suspected to interfere with reproductive or metabolic function in the past 2 months (e.g., contraceptives, metformin, steroids, anti-seizure medications) * Untreated and/or unstable medical or mental health condition known or suspected to interfere with reproductive or metabolic function * Currently pregnant or breast…
Locations (3)
- Children's Mercy HospitalKansas City, Missouri
- Cornell University - Human Metabolic Research UnitIthaca, New York
- University of Rochester, Strong Fertility CenterRochester, New York