Cerebral Hemodynamics- ICHOR II
Matthew Borzage
Summary
This is a randomized controlled trial in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two types of anesthesia: propofol or sevoflurane. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of propofol and sevoflurane are in clinical equipoise will be offered to have the anesthesia they will receive during their MRI randomized. All eligible subjects will be asked to provide informed consent before participating in the study.
Description
This is a randomized controlled trial in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two types of anesthesia: propofol or sevoflurane. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of propofol and sevoflurane are in clinical equipoise will be offered to have the anesthesia they will receive during their MRI randomized. All eligible subjects will be asked to provide informed consent before participating in the study. Treatm…
Eligibility
- Age range
- Up to 1 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients who are scheduled for a clinically indicated MRI at the sponsor institution. * Patients who are able to tolerate an MRI. * Patients who require clinical anesthesia for their MRI. * Patients with conditions not believed to alter oxygen metabolism or blood flow in the brain, including but not limited to patients with orthopedic indications, undescended testicles, hernia repairs, term equivalent age scans. * Patients who have no medical conditions that make the use of propofol or sevoflurane better for their clinical outcome. * Patients between birth and up-to 1 ye…
Interventions
- DrugPropofol or Sevoflurane
Patient's will be randomized to the group receiving propofol, or the group receiving sevoflurane.
Location
- Children's Hospital Los AngelesLos Angeles, California