Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy
Massachusetts Eye and Ear Infirmary
Summary
This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.
Description
Fuchs Endothelial Corneal Dystrophy (FECD) is the most common corneal endothelial disorder and has been estimated to affect approximately 4% of the US population over the age of 40. Corneal transplantation is currently the primary treatment modality available to treat FECD, and there are no medical therapies that treat the disease or stall its progression. Therefore, there is an unmet need to identify pharmacotherapeutic interventions that would prevent the endothelial cell loss in early through late stages of FECD, as well as after corneal transplantation, aiding in the survival of the cornea…
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Male or female ≥21 years of age at time of surgical evaluation. 2. Diagnosis of advanced FECD and visually significant cataract 3. Indication for DMEK (Descemet Membrane Endothelial Keratoplasty) with concurrent cataract surgery 4. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study. 5. Willingness and ability to adhere to medication regimen Exclusion Criteria: 1. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study. 2. History of prior intraocular surgery in s…
Interventions
- DrugN-acetyl cysteine (NAC) 10% solution
N-acetyl cysteine is a sterile, unpreserved eye drop containing 10% (100 mg/mL) of acetylcysteine.
- DrugN-acetyl cysteine (NAC) 20% solution
N-acetyl cysteine is a sterile, unpreserved eye drop containing 20% (200 mg/mL) of acetylcysteine.
- DrugVisine Dry Eye Relief eye drops
Visine Tears Dry Eye Relief artificial tears ophthalmic solution
Location
- Massachusetts Eye and Ear InfirmaryBoston, Massachusetts