Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
Augusta University
Summary
The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.
Description
Preliminary data from the investigators' laboratory demonstrate a negative relationship between hemoglobin A1c (HbA1c) and ETBR function, supporting ETBR may be dysfunctional in the presence of T1D. Using near infrared spectroscopy (NIRS) to non-invasively assess muscle function, the investigators have also observed reduced skeletal muscle mitochondrial function in people with T1D compared to healthy controls. In addition, reduced circulating Sirt1 is associated with both ETBR and skeletal muscle mitochondrial dysfunction in the general population. For the current application, the investigator…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Men and premenopausal women * All races * Clinical diagnosis of insulin-dependent type 1 diabetes (patients only) Exclusion Criteria: * Clinical diagnosis of hepatic, cardiovascular, or renal disease * Uncontrolled diabetes (HbA1C \>12%) * Diabetic complications (i.e. neuropathy) * Uncontrolled hypertension (\>140/90 mm Hg on therapy) * Pregnancy * Use of vasoactive medications
Interventions
- DrugResveratrol
500 mg of oral trans-resveratrol twice daily (in the morning and evening) for 12-weeks
- OtherPlacebo
placebo for 12 weeks
Location
- Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise PhysiologyAugusta, Georgia