A Randomized Trial to Minimize Non-Response to Aerobic Training in Post-Menopausal Women With Early Stage Breast Cancer
Memorial Sloan Kettering Cancer Center
Summary
This study will compare the effects on cardiorespiratory fitness (CRF) of aerobic exercise in different amounts (number of minutes/session) over different periods of time (number of weeks). Aerobic exercise is physical activity of light-to-moderate intensity that uses the large muscle groups (muscles in your legs, buttocks, back, and chest) and can be performed for at least 10 minutes. The researchers will study the effects of different exercise programs on how well the study participants' bodies use oxygen, how well their heart pumps blood, how well their lungs function, and how healthy their blood vessels are.
Description
Prior to the initiation of every supervised aerobic training session, patient resting vital signs will be assessed to ensure the patient can safely proceed with the session. Vital signs, including resting heart rate and blood pressure, will be collected and monitored per ExOnc program guidelines. In addition, the planned session will not be initiated if the ExOnc staff member observes any concerns that may compromise participant safety and/or the integrity of the planned session. Vital sign monitoring guidelines for unsupervised sessions, prescribed at lower intensities, will be advised by the…
Eligibility
- Age range
- 21–80 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Aged 21-80 years * Female * Surgically resected early stage (I-III) primary breast cancer * Post-menopausal, defined as one of the following: * Age ≥ 45 with no menses for at least 2 years * Chemically and/or surgically induced menopause through ovarian suppression, as determined by the primary oncologist * Estradiol level of ≤30 pg/mL * An interval of at least one year, but no more than five years, following the full completion of definitive therapy for malignant disease. Definitive therapy is defined as: * Surgery plus radiation * Surgery plus chemotherapy…
Interventions
- OtherAerobic Training
300 min/wk for 16 weeks
- OtherAerobic Training
150 min/wk for 32 weeks
- OtherAerobic Training
300 min/wk for 32 weeks
- OtherAerobic Training
150 min/wk for 16 weeks
Locations (2)
- Hartford Healthcare Cancer Institute @ Hartford Hospital (Data Collection Only)Hartford, Connecticut
- Memorial Sloan Kettering Cancer CenterNew York, New York