University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
Summary
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers include neurobehavioral testing, neuroimaging, electroencephalography, cognitive testing, vocal recordings, epi/genetic testing, and autonomic nervous system measures (i.e. "fight-or-flight" response). The results obtained from this study may provide novel antidepressant treatment response biomarkers, with the future goal of targeting a given treatment to an individual patient ("personalized medicine").
Description
Treatment response biomarkers in TRD and OCD have been and will remain an active area of research. Interventional treatments in psychiatry, e.g. ECT, TMS, racemic ketamine infusions and intranasal esketamine insufflations, offer exciting opportunities for biomarker discovery due their procedural nature (obviating concerns for treatment non-adherence in non-supervised settings), more rapid-onset, and larger effect sizes than typically seen with traditional antidepressant medications or evidence-based psychotherapies. Although no well-replicated TRD biomarkers have been approved for standard cli…
Eligibility
- Age range
- 18–99 years
- Sex
- All
- Healthy volunteers
- No
INCLUSION CRITERIA: 1. 18-99 years of age 2. English-speaker with a level of understanding sufficient to agree to clinical treatment with a treatment modality offered by the Interventional Psychiatry Service, all required research procedures, and sign an informed consent document 3. Clinical diagnosis of a major depressive episode in the context of major depressive disorder or bipolar disorder or treatment-resistant OCD evaluated by a provider on the Interventional Psychiatry Service and felt to be an appropriate candidate for clinical treatment with a treatment modality offered by the Interv…
Interventions
- DeviceElectroconvulsive Therapy (ECT)
ECT for the treatment of treatment-resistant depression OR Bipolar Disorder in an active major depressive episode
- DeviceTranscranial Magnetic Stimulation (TMS)
TMS for the treatment of treatment-resistant depression in an active major depressive episode
- DrugKetamine
Intravenous ketamine infusion for the treatment of treatment-resistant depression in an active major depressive episode
- DrugEsketamine
Intranasal esketamine insufflation for the treatment of treatment-resistant depression in an active major depressive episode
- DeviceDeep Transcranial Magnetic Stimulation (dTMS)
TMS for the treatment of OCD
Location
- University of Iowa Health CareIowa City, Iowa