Columbia University
The primary objectives of this study are to: (1) determine the impact of glomerular disease on bone strength and (2) investigate the pathophysiologic underpinnings of impaired bone strength in glomerular disease.
Children and adults with glomerular disease have unique and potentially modifiable risk factors for compromised bone health, but our current understanding of skeletal fragility in glomerular disease is lacking. In the first large population-based cohort study, we recently found that primary glomerular disease was independently associated with an increased risk of incident fracture, and that hip fracture risk was \>2-fold greater in patients younger vs. older than 40 years of age. Mechanisms that drive increased fracture risk in glomerular disease are not clear but likely multifactorial. Our pr…
Inclusion Criteria for participants with glomerular disease: 1. CureGN participant or CureGN Eligible CureGN eligible is defined as having a diagnosis of Glomerulonephropathy (GN). Patients would otherwise be enrolled in be in CureGN study, except for lacking a minor entry criteria, such as: 1. First diagnostic kidney biopsy within 5 years of CureGN study enrollment 2. Access to first kidney biopsy report and/or slides or not being interested in study participation. 2. Males or females 5 to 55 years (premenopausal for women) 3. Females must have a negative urine/serum pregnancy test…
DXA whole body, hip, spine, and radius at baseline, and 12-month visit.
HR-pQCT of the radius and tibia at baseline, and 12-month visit.
The blood draw can be completed +/- 3 weeks from baseline or 12-month visit.
Questionnaires regarding fracture history, physical activity and dietary intake at baseline, and 12-month visit.
Arctuva estimate
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