Sleep and Circadian Regulation in Diabetic Retinopathy: The Role of Intrinsically Photosensitive Retinal Ganglion Cells and Melatonin Supplementation
University of Illinois at Chicago
Summary
This study explores the use of melatonin in patients with diabetic retinopathy
Description
This is a randomized controlled study using melatonin for 8 weeks in patients with diabetic retinopathy on outcomes of sleep and circadian regulation
Eligibility
- Age range
- 40–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Type 2 diabetes (clinically diagnosed, taking anti-diabetes medications or history of elevated A1C≥6.5%) * 40-65 years of age * Diabetic retinopathy of at least moderate degree Exclusion Criteria: * use of melatonin * antidepressants or antipsychotics * illicit drug use * night shift work or travel beyond 2 time zones in the month before enrollment * end stage renal disease requiring renal replacement therapy * history of stroke or transient ischemic attacks * history of dementia or memory impairment * uncontrolled congestive heart failure or recent hospitalization for…
Interventions
- DrugMelatonin
Melatonin 3 mg will be taken nightly for 8 weeks
- OtherPlacebo
Placebo will be given nightly for 8 weeks
Location
- University of Illinois at ChicagoChicago, Illinois