Stress and Congestive Heart Failure
Yale University
Summary
The purpose of this study is to investigate whether acute stress can precipitate congestive heart failure (CHF) exacerbation in patients with CHF.
Description
Study participants will be followed for 6 months. Patients will undergo a laboratory mental stress protocol, and a field protocol using ecological momentary assessment (EMA) to, 1) test the effects of psychological stress and negative emotion on pulmonary artery pressure (PAP) in HF patients; 2) examine the relationship of stress-induced PAP change to HF exacerbation; and 3) identify a risk profile by exploring predictors of heterogeneity in the PAP response to stress, including physiological variables (e.g., NYHA class, biomarkers), sleep, quality, and psychosocial variables (e.g., sources of…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: -Heart failure patients over 18 who have or will be receiving a Cardiomems implanted PAP monitor. Exclusion Criteria: * Patients who are unable to perform EMA or laboratory assessments due to cognitive, visual, language, or other disabilities will be excluded. * Patients with Class IV heart failure will also be excluded, as they are already maximally decompensated, and a ceiling/floor effect would preclude effects of stress. * Patients with conditions other than heart failure that affect PA pressures (e.g. dialysis). * Patients with physical conditions that interfere wit…
Interventions
- OtherMental Stress
Patients will undergo a lab mental stress protocol, and a field protocol using ecological momentary assessment (EMA) to test the effects of psychological stress and negative emotion on PAP in HF patients.
Locations (2)
- St. Francis HospitalHartford, Connecticut
- Yale UniversityNew Haven, Connecticut