Massachusetts General Hospital
The goal of this research is to determine (1) the feasibility of tethered capsule OCT esophageal imaging in the Parkinson's Disease population; (2) the morphologic changes in the enteric nervous system of the esophagus in patients with Parkinson's disease.
The purpose of this study is to establish the esophageal pathology findings as imaged with tethered capsule microscopy in participants with Parkinson Disease. Images from participants with Parkinson disease will be compared to our previously obtained images in healthy participants to establish the spectrum of esophageal pathologies occurring in participants with Parkinson disease by OCT imaging. In the case of imaging internal luminal organs, like the esophagus, OCT light is delivered via a long catheter. We have developed a new technique termed Tethered Capsule Endomicroscopy (TCE). TCE invo…
Inclusion Criteria: * Idiopathic Parkinson's disease as defined by the United Kingdom PD Society Brain Bank Criteria * Parkinson Disease Hoehn and Yahr stage 2-4 * Participants on stable dose of Parkinson Disease medications for at least 4 weeks prior to the study screening * Participants between 40 and 85 years old * Participants who are capable of giving informed consent Exclusion Criteria: * Atypical or secondary Parkinson Disease * Esophageal fistula and/or esophageal strictures with a luminal stricture diameter that is smaller than the diameter of the capsule * Recent intestinal resect…
Participants will be asked to swallow the TCE. They may use mild numbing spray, and lubrication spray to help swallowing. Imaging will be conducted once the TCE is past the pharynx. We will advance the TCE until the stomach and then slowly pull the TCE back up the esophagus. This may be repeated twice.
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