Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth
University of Colorado, Denver
Summary
To evaluate the effect of estradiol with or without a prior gonadotropin releasing hormone analogue on insulin sensitivity and vascular function in transgender females compared to cisgender controls.
Eligibility
- Age range
- 13–16 years
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria (transgender females): * Identify as a transgender female * Age 13-16 years at the time of enrollment * If on a gonadotropin releasing hormone analogue, \> 6 months exposure * Plan to start estradiol clinically in \< 4 months Inclusion Criteria (cisgender males and females): * Males and females ages 13-16 years Exclusion Criteria: * Cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures * Antipsychotic medication use * Type 1 or 2 diabetes (by medical history) * Polycystic ovarian syndrome (PCOS for cisgender females) * Hy…
Location
- Children's Hospital ColoradoAurora, Colorado