Rush University Medical Center
This study will evaluate the efficacy of biologic augmentation of ACL reconstruction with bone marrow derived mesenchymal stem cells as measured by magnetic resonance imaging to detect graft healing and integration. Secondary endpoints will include validated patient reported outcome measures, as well as functional outcome using objective examination findings.
Introduction Anterior cruciate ligament (ACL) tears are a common and devastating injury among young athletes, and re-injury poses significant threats to both successful return to play and long term outcomes. Graft healing during ACL reconstruction (ACLR) is a slow biologic process, that involves graft incorporation into bone tunnel sites, as well as intra-articular graft remodeling . The intra-articular graft remodeling process is known as ligamentization, and occurs in three phases after ACLR. The first phase of early healing occurs between 0 and three months, the second phase occurs between…
Inclusion Criteria: * English-speaking patients * 18-60 years of age with acute ACL injury (\<6 months from time of injury to reconstruction) and undergoing reconstruction with patellar tendon allograft * Written informed consent is obtained Exclusion Criteria: * Revision Surgery * Prior history of knee surgery * Concomitant ligamentous injury * Inability to obtain an MRI * Inability to participate in follow-up for the study * Any patient lacking decisional capability * Diagnosed musculoskeletal cancer or any diagnosed cancer, other than * musculoskeletal if not on long term remission (e.g.…
Autologous Bone Marrow Derived Mesenchymal Stem Cells injected into the ACL allograft prior to graft implantation.
Small incision over the site where bone marrow aspirate would have been obtained
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