Shirley Ryan AbilityLab
The use of acute intermittent hypoxia (AIH) has been examined in animal and human studies to gain an understanding of its effect on spinal excitability and synaptic strength. Subsequently, the investigators have learned that the use of AIH results in new protein formation and spinal plasticity. The use of acute intermittent hypoxia demonstrates a potential for therapeutic utilization in individuals with neurologic injuries. However, little is known about the effect of AIH in healthy individuals. This work is necessary to understand the mechanisms of AIH-induced plasticity. As such, this research study seeks to evaluate the impact of a single session AIH on upper extremity motor function in healthy individuals.
The use of acute intermittent hypoxia (AIH), has been demonstrated, through human and animal studies, to be an effective way of increasing spinal motor excitability and strengthening residual synaptic connectivity. AIH utilizes short duration (\<2 min) exposures to reduced oxygen levels (\~10% inspired oxygen), with alternating exposures to air with normal oxygen levels (\~21% inspired oxygen). Previous publications demonstrate that AIH is a safe and effective intervention to modify motor function in individual with chronic incomplete spinal cord injuries. The use of AIH has been shown to inf…
Inclusion Criteria: * No history of neurologic injury or progressive neuromuscular disorder * Individuals ages 18-70 years old * Must be medically stable with no history of cardiovascular instability, congestive heart failure or stroke * Not currently (\>2 weeks) on any medications related to spasticity * No history of Sleep apnea * Not a current smoker * Able to comply with protocol/study requirements Exclusion Criteria: * Recent change in the use of narcotic, anti-inflammatory or pain medication * unstable medical conditions or any other clinical observation that may affect the candidate'…
30 minute session of Acute Intermittent Hypoxia
30 minute session of Sham Acute Intermittent Hypoxia
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