Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment
Vanderbilt University Medical Center
Summary
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Eligibility
- Age range
- 40+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion criteria: * Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center * Planned clinical electrode trajectory that contacts caudate * Age greater than or equal to 40 * Diagnosis of Parkinson's disease * Able to participate in intraoperative testing * English speaking Exclusion criteria: * Age less than 40 * Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions) * Movement disorder other than Parkinson's disease
Interventions
- OtherNeurophysiology recordings
Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated
- OtherNeural stimulation
Neural stimulation will be delivered during a gambling task and its impact on task performance quantified
Location
- Vanderbilt University Medical CenterNashville, Tennessee