Identifying Modifiable PAtient Centered Therapeutics Frailty: An Observational Cohort Study
University of California, Los Angeles
Summary
Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.
Description
Frailty is the decline in physical and cognitive reserves leading to increased vulnerability to stressors such as surgery or disease states. Frailty is not a disease, but a syndrome with a distinct frail phenotype that includes decreased status in mobility, muscle mass, nutritional status, strength, and endurance. Frail patients are at greater risk of adverse outcomes, such as functional decline, prolonged hospitalization with associated increases in healthcare costs and death. Multiple measures of frailty exist and although they are important for understanding risk for a given patient populat…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU * ICU stay longer than 24 hours Exclusion Criteria: * Patients with muscular or mitochondrial diseases affecting muscle quality or mass * Preexisting paralysis * Absence of lower limbs * Ongoing discussions about goals of care * Transfers from a skilled nursing facility * Children under the age of 18
Interventions
- Diagnostic TestUltrasound
2D ultrasound image collection
- Diagnostic TestBiomarker Analysis
Inflammatory and nutritional biomarker analysis
- OtherFrailty Index
A Frailty Index Questionnaire be completed by patients or their surrogates to determine the presence of frailty at ICU admission
Location
- Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative MedicineLos Angeles, California