Dexmedetomidine for Treatment of Shivering During Scheduled Elective Cesarean Delivery: Determining the Optimal Dose
Mayo Clinic
Summary
The purpose of this study is to determine the optimum dose of Dexmedetomidine to stop shivering in 90% of patients who experience shivering during scheduled elective cesarean deliveries.
Description
Potential subjects will consist of parturients who present for scheduled elective cesarean deliveries. Patients will be recruited and consented for the study pre-operatively and if they display Grade 3 or 4 shivering at the time of delivery then they will be enrolled in the study. Doses of dexmedetomidine will be selected according to a sequential up-and-down method, using a biased coin design to find the estimated dose at which 90% of patients would have desired effect - cessation of shivering within 5 minutes of medication administration. An anesthesia physician not involved in patient care…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Women presenting for planned cesarean delivery. * American Society of Anesthesiology Physical Classification Status 2 or 3; without major medical co-morbidities. * Singleton gestation in the 3rd trimester (28-42 weeks gestation). * Spinal anesthesia technique Women presenting for planned cesarean delivery. * American Society of Anesthesiology Physical Classification Status 2 or 3; without major medical co-morbidities. * Singleton gestation in the 3rd trimester (28-42 weeks gestation). * Spinal anesthesia technique. Exclusion Criteria: * Any contraindication to spinal a…
Interventions
- DrugDexmedetomidine
Doses of dexmedetomidine will be selected according to a sequential up-and-down method, using a biased coin design to find the estimated dose at which 90% of patients would have desired effect
Location
- Mayo Clinic in RochesterRochester, Minnesota