The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU
Massachusetts General Hospital
Summary
The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.
Description
Intensive care unit (ICU) environments do not support sleep or preserve circadian rhythms of postoperative critically ill patients. Among the contributing factors is the common practice of administering nutrition support through feeding tubes overnight. The overall objective of the study is to examine a novel dimension of clinical nutrition by determining whether enhancing sleep quality and preserving robust circadian rhythms through daytime instead of overnight feeds will attenuate inflammation and improve cardiometabolic profiles of postoperative cardiac ICU patients on nutrition support. Th…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adult male or non-pregnant female volunteers (age 18+) * Scheduled for a cardiac surgical procedure with planned post-operative admission to the ICU for \>48 hours * Able and willing to give consent and comply with study procedures Exclusion Criteria: * Blind, deaf or unable to speak English * Women who are pregnant or nursing * Contraindications to safe use enteral nutrition, including gastrointestinal obstruction * Personal history of intestinal malabsorption, gallbladder disease or pancreatitis * Dietary restrictions precluding enteral feeds * Renal and liver failur…
Interventions
- Dietary SupplementTime-of-day of enteral nutrition provision (daytime first)
Enteral nutrition (tube feeds) will be provided during the daytime followed by nighttime.
- Dietary SupplementTime-of-day of enteral nutrition provision (nighttime first)
Enteral nutrition (tube feeds) will be provided during the nighttime followed by daytime.
Location
- Massachusetts General HospitalBoston, Massachusetts