Minimal Residual Disease Assessment in Colorectal Cancer (MiRDA-C)
M.D. Anderson Cancer Center
Summary
This study investigates if circulating tumor DNA (ctDNA) and other tumor-related molecules/chemicals released in the blood can help doctors predict if colorectal cancer may come back or spread. Tumors shed DNA and other cancer related chemicals into the blood that can be identified and studied further to provide information about the cancer. Information gathered from this study may help researchers better understand if ctDNA found in the blood can predict whether colorectal cancer may come back or spread.
Description
PRIMARY OBJECTIVES: I. Demonstrate ability to monitor cancer-specific deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and proteomic alterations from plasma. II. Improve detection of recurrences post completion of curative therapies through monitoring of plasma cancer-specific DNA, RNA and proteomic alterations. SECONDARY OBJECTIVES: I. Qualitative and quantitative changes in cancer-specific plasma alterations during neoadjuvant, adjuvant therapies and surveillance. II. Disease free survival (DFS) of patients with detectable cancer-specific plasma alterations. III. Overall survival (…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age ≥ 18 years. 2. Histological/cytological confirmation of colorectal adenocarcinoma. 3. Patients with any stage colorectal adenocarcinoma deemed potentially eligible for curative intent treatment. Patients with stages II-IV colorectal cancer post-R0 resection may also be enrolled onto the protocol any time before or up to 3 months post-surgery and prior to initiating adjuvant therapy. 4. Ability to understand and the willingness to sign a written informed consent document. 5. Willing to pursue standard of care surveillance post completion of curative therapies. 6. Wil…
Interventions
- ProcedureBiospecimen Collection
Undergo collection of blood and tissue samples
- OtherElectronic Health Record Review
Review of medical records
Locations (10)
- Banner - MD Anderson Cancer CenterGilbert, Arizona
- Baptist- MD Anderson Cancer CenterJacksonville, Florida
- The Queen's Medical CenterHonolulu, Hawaii
- St. Luke's Cancer InstituteBoise, Idaho
- Cooper Hospital UNIV MED CTR.Camden, New Jersey
- UT Southwestern/Simmons Cancer Center-DallasDallas, Texas