Adams Clinical
TRAIT is an open-label observational study to evaluate treatment response to selective-serotonin reuptake inhibitors (SSRIs) and selective-norepinephrine reuptake inhibitors (SNRIs) among individuals meeting criteria for Major Depressive Disorder (MDD) and seeking enrollment in investigational trials.
Inclusion Criteria: * Participant has signed an ICF prior to any study-specific procedures being performed. * Participant is male or female of age ≥ 18 years old. * Participant has a diagnosis of MDD as confirmed by the MINI semi-structured diagnostic interview and ≥ 14 HAM-D total score. * Participant is in good physical health and, in the opinion of the investigator, is a suitable candidate for treatment with an ADT. Exclusion Criteria: * Participant is pregnant, breast-feeding, or planning to become pregnant. * A history or presence of a clinically significant hepatic, renal, gastrointes…
Protocol-approved antidepressant treatments (ADT) will be prescribed in accordance with standard of care, whenever possible following dosing recommendations within the Study Formulary and Prescribing Guidelines (Sertraline 100 mg/day; Citalopram 20 mg/day; Escitalopram 10 mg/day; Fluoxetine 20 mg/day; Paroxetine 20 mg/day; Duloxetine 60 mg/day; Buproprion 300 mg/day; Desvenlafaxine 50 mg/day; Venlafaxine 150 mg/day). ADTs may be up or down-tapered as necessary.
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