The Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by Impedance Cardiography in Early Pregnancy
Marshall University
Summary
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy. Patients will be given medication based on their hemodynamics and asked to return for a repeat measurement.
Description
When a patient presents to the Maternal Hypertension Center at Cabell Huntington Hospital, she will receive a non-invasive hemodynamic assessment via the NICaS system as per usual protocol. The NICaS system uses impedance cardiography which provides a reliable assessment of cardiovascular, respiratory, and fluid parameters. In typical practice, the vasodilator nifedipine is initiated for increased systemic vascular resistance and elevated cardiac output is treated with beta blockade (via either atenolol or labetalol). The medication to be given to each subject will be based on their hemodynami…
Eligibility
- Age range
- 18–45 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Patients presenting to Maternal Hypertension Center at Cabell Huntington Hospital * English speaking * 18-45 years old. * Willing to provide informed consent * Gestational age prior to 15 weeks gestation Exclusion Criteria: * Non-English speaking patients, patients * \<18 years old or \>45 years old * Not willing or able to provide consent * Gestational age \>15 weeks
Interventions
- DrugLabetalol
Beta blocker
- DrugAtenolol
Beta blocker
- DrugNifedipine
Calcium channel blocker
Location
- Maternal Hypertension Center at Cabell Huntington HospitalHuntington, West Virginia