Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
Northwell Health
Summary
The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation
Eligibility
- Age range
- 18–85 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * the diagnosis of Essential Tremor, made by a movement disorder neurologist, where tremor is not secondary to any disease process or traumatic insult * distal appendicular tremor, with minimal proximal component * tremor refractory to multiple medication regimens and/or where the medications cause intolerable side effects * tremor judged to be severely impacting their quality of life. Exclusion Criteria: * significant neurological disorder * significant dementia or neurocognitive limitations as assessed by neuropsychiatry (when necessary) * severe psychiatric illness wi…
Interventions
- DeviceDeep Brain Stimulation
Medtronic Activa device will be implanted and administered clinically, except as part of the trial after 24 months of DBS being on it will be turned off for 3 days and will be turned back on.
Location
- North Shore University HospitalManhasset, New York