Intermittent Fasting as a Primary Means for Improving Quality of Life for Acute and Chronic Pancreatitis
H. Lee Moffitt Cancer Center and Research Institute
Summary
The purpose of this research is to compare intermittent fasting with a standard diet approach for improving the quality of life related to your pancreas disease. Our hope is to improve your symptoms and prevent you from needing to go into the hospital for pancreas-related issues.
Description
Fasting is a classic means for religious discipline, yet recently regaining favor in the medical landscape. Numerous studies have come forth, both in animals and humans outlining the benefit of intermittent fasting (IF) on various disease states and longevity. Though a relatively complex cellular process, fasting for at least 8-12 hours has been shown to lead to fatty acid release from a patient's adipose storage. These fatty acids then shuttle to the liver, where they are converted to ketones such as beta-hydroxybutyrate and acetoacetate. Ketones are then utilized for energy sources in the h…
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age ≥ 18 year * Recurrent acute pancreatitis defined by greater than 2 episodes of pancreatitis, defined by: abdominal pain and either amylase or lipase \> 3 x the upper limit of normal, imaging suggestive of, separated by time * Anatomy of chronic pancreatitis defined by Rosemont criterion9 or on imaging (CT, MRI) * Pancreatic exocrine insufficiency defined by a pancreatic elastase \< 200 ug/g stool10 Exclusion Criteria: * Age \< 18 years * Pregnant Patients * Age \> 80 years * Patients who cannot consent for themselves * Glycogen storage disease * Insulinoma or hyp…
Interventions
- OtherIntermittent Fasting
These subjects will will then receive information regarding intermittent fasting, which would include fasting for a 16-hour period each day, followed by ingestion of an appropriate number of calories for the remaining part of the day. See attached IF Quick Facts for details provided to the patient.
- OtherNo intermittent fasting
These subjects will undergo standard caloric dietary guidance. Patients in group B will also be given the above information, though not be asked to intermittently fast
Location
- Moffitt Cancer CenterTampa, Florida