Adjuvant Checkpoint Blockade Plus Radiation In Locally Advanced, Mismatch Repair Deficient/Microsatellite Instability-High (MMR-D/MSI-H) Endometrial Cancer
Memorial Sloan Kettering Cancer Center
Summary
This study will test whether the combination of radiation and Dostarlimab is an effective treatment for women with MMR-D/MSI-H endometrial cancer who have recently undergone surgery.
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Age 18 years or older * ECOG performance status 0-1 * Endometrial cancer: all histologies (submission of pathology report is required for all patients who underwent surgery outside of MSK) * MMR-D or MSI-H or POLE-mutated (submission of report\[s\] required for. patients who underwent testing outside of MSK POLE-mutated endometrial cancers will be included regardless of MMR/MSI status and limited to up to 3 patients per group. * Patients with hypermethylation of MMR gene promoters (MLH1, MSH2, MSH6 or PMS2) will be included * POLE-mutated endometrial cancers will be…