Neural Correlates of Stress and Perceived Control in Adolescent Depression
Mclean Hospital
Summary
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.
Description
Participants in this research will include 40 female adolescents, aged 14-18, with Major Depressive Disorder (MDD) and 40 healthy adolescents from the greater Boston area by Dr. Emily Belleau, at McLean Hospital's Center for Depression, Anxiety and Stress Research. The study will include four sessions: * A clinical diagnostic interview as well as filling out a series of questionnaires and assessments. * The second session will include a functional magnetic resonance imaging (fMRI) brain scan to be conducted at the McLean Hospital Imaging Center. Participants will be asked to respond to surve…
Eligibility
- Age range
- 14–18 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Inclusion Criteria: All Participants 1. Females of all ethnic origins See Section: Inclusion of Women and Minorities); 2. Ages 14-18 (See Section: Inclusion of Children); 3. Written informed assent/consent from adolescent and parent/guardian (if under age 18); 4. English as a first language or English fluency; 5. Right handed111; 6. Personal cell-phone (for Ecological Momentary Assessment \[EMA\]) 7 All participants will be in the follicular phase of their menstrual cycle when completing the functional magnetic resonance imaging (fMRI) study session Inclusi…
Interventions
- BehavioralComputer Task Manipulation
Participants will complete computer tasks.
Location
- McLean HospitalBelmont, Massachusetts