Massachusetts General Hospital
This study will investigate the role of coordinated brain rhythms during sleep in memory consolidation and determine whether playing precisely timed brief bursts of noise can enhance these rhythms and improve memory in epilepsy inpatients with implanted hippocampal electrodes.
The investigators will test the hypotheses that coordinated brain rhythms during nonrapid eye movement sleep are associated with memory consolidation and can be enhanced with auditory stimulation (playing precisely timed brief bursts of quiet noise) to improve memory. The investigators will measure differences in sleep and memory performance in epilepsy inpatients with implanted hippocampal electrodes and continuous full scalp EEG monitoring under three overnight sleep conditions: a baseline night; a memory night during which sleep-dependent memory consolidation is assessed with the finger tap…
Inclusion Criteria: * Inpatients with epilepsy * Aged 12-65 * Undergoing clinically indicated continuous scalp and intracranial EEG monitoring with implanted hippocampal electrodes * Fluent in English * Able to give informed consent/assent (for minors aged 12-17 or adults with an appointed guardian) Exclusion Criteria: * Intellectual disability impairing ability to perform task * Motor problems that preclude finger tapping task * Previous surgery anticipated to disrupt coordination of sleep oscillations in the circuitry of interest
Hippocampal and scalp EEG monitoring during overnight sleep
Training on the finger tapping MST prior to monitored overnight sleep with MST testing the following morning
Training on the finger tapping MST prior to monitored overnight sleep that includes auditory stimulation, with MST testing the following morning
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