T Cell Profiling in Patients with Multiple Sclerosis
Boston Children's Hospital
Summary
The goal of this research study is to to learn more about the body's immune response in patients with multiple sclerosis (MS). In MS, the body's immune cells mistakenly attack an important part of the nerves of the brain and spinal cord. The immune cells responsible for attacking the nerves in MS patients is primarily the T cells. A marker was recently discovered that might specifically identify these damaging T cells from all other T cells in the body. Understanding which T cells cause the damage in MS patients and understanding more about these specific T cells may help doctors better understand how MS occurs and could possibly prevent MS in the future.
Eligibility
- Age range
- 13–20 years
- Sex
- All
- Healthy volunteers
- No
MS Group Inclusion criteria -diagnosis of multiple sclerosis and present to the neurology clinic for a regular checkup or are admitted to the inpatient floor with acute symptoms. Exclusion criteria * Have an active infection * Take T cell modulating drugs Control Group Inclusion criteria -scheduled for elective surgery * without any immunological diseases. Exclusion criteria * Have an active infection.
Interventions
- OtherBlood Sample
a blood sample will be collected
Location
- Boston Children's HopsitalBoston, Massachusetts