Association of Periodontal Inflammation on Immune Response in Wound Healing
University of Nebraska
Summary
Subjects who are in need of extraction of a posterior tooth will be recruited for this study. Prior to extraction, periodontal clinical markers of inflammation, body-mass index and dental radiographs will be measured/taken. The posterior tooth will be atraumatically extracted and a small soft tissue biopsy of the extraction site will be taken. At the two week follow-up, sutures will be removed and another small biopsy of soft tissue will be taken. Subjects will be seen again at 3 months for a final collection of clinical data and radiographs.
Description
Twenty-five healthy adult subjects (aged 21-70) requiring extraction of a posterior tooth will be recruited for this study. Prior to extraction, a limited-view cone beam computed tomography radiograph will be taken as well as clinical measures of periodontal inflammation (probing depths, recession, bleeding on probing, gingival crevicular fluid sampling). The extraction will be completed atraumatically and with local anesthesia. Following extraction, a small biopsy of the soft tissue of the extraction site will be taken and the site then sutured. At the two-week postoperative visit, sutures wi…
Eligibility
- Age range
- 21–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * non-restorable posterior tooth (molar/premolar) in need of extraction Exclusion Criteria: * systemic disease that effects inflammation
Interventions
- ProcedureDental Extraction
Extraction
Location
- University of Nebraska, College of DentistryLincoln, Nebraska