Rutgers, The State University of New Jersey
The purpose of the research is to determine if changes seen during sulforaphane treatment (a compound that comes from eating certain vegetables) can better be understood using digital biomarkers. These digital biomarkers are things like heart rate, muscle movement etc. and are measured using non-invasive devices (like a watch) and are aimed at complementing the traditional clinical scores already in use in current trials (e.g. Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Ohio Autism Clinical Impressions Scale (OACIS)).
This study is a pilot open label treatment trial with SF (sulforaphane) in 10 individuals that have completed with moderate to severe autism, age 13-30 years that have completed participation in ClinicalTrials.gov Identifier: NCT02677051. This study will measure digital biomarkers of the nervous systems. Digital biomarkers are obtained by using non-invasive wireless (wearable, like wearing a watch) biosensors that co-register in tandem multiple biorhythms self-generated by the person's nervous systems. These sensors gather a very large amount of data from measures such as EEG (electroencephalo…
Inclusion Criteria: * Autistic disorder diagnosis. * Age between 13-30 years. * Male gender. * Participated in clinical trial NCT02677051 Exclusion Criteria: * Those that started or continued taking Avmacol® or similar broccoli extracts since leaving our double-blind study. * Absence of a parent or legal guardian and consent, * Those that can not or will not complete all visits and adherence to study regimen. * Seizure within 2 years of screening, * History of chronic kidney, liver or thyroid disease. * Impaired renal function (serum creatinine\> 1.2 mg/dl). * Impaired hepatic function (\>…
Sulforaphane comes from eating certain cruciferous vegetables. In this case the pills are made from broccoli seeds.
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